Sulbutiamine is a synthetic derivative of thiamine that potentiates interesting nootropic benefits with fatigue, memory, mood and focus. Sulbutiamine essentially is thiamine (B1) that is bound together at the thiol group, allowing it to more easily cross the blood-brain barrier and increase the levels of thiamine and thiamine phosphate esters in the brain.

Sulbutiamine  Thiamine This simple alteration in molecular structure increases liphophilicity and thereby blood brain barrier (BBB) penetration.

How does Sulbutiamine and Thiamine work?

To help understand better the importance of thiamine on the mind, we should first look and see what is rendered by a deficiency. A condition known as beriberi--one that is usually common only to alcoholics and people with poor nutrition--is directly caused by a deficiency in vitamin b1. Moreover, beriberi is mostly seen in areas that depend heavily on rice as a form of nutrition; in fact, the condition was common enough to warrant the discovery of this molecule from a nation that depends on rice (Japan). The effects of beriberi are heavily weighted neurologically, and can result in:

Difficulty in walking

Tingling or loss of feeling (sensation) in hands and feet (numbness)

Loss of muscle function or paralysis of the lower legs

Mental confusion/speech difficulties

Pain

Involuntary eye movements (nystagmus)

Vomiting

Although, this does not imply that boosting your brain B1 will yield positive benefit, the removal or negative effect becomes obvious, thiamine is doing something neurologic.

Possible Sulbutiamine Benefits

With that said, sulbutiamine has actually been found to have positive benefits, mainly centered around countering central asthenia (mental fatigue). Sulbutiamine has also been shown to potentiate cholinergic effects in the hyppocampus, which is the center of new memory formation. Furthermore, mice studies have illustrated significant results in object recognition and operant conditioning, implying an positive effect on memory and learning. While the effects differ widely, as with any nootropic, the following benefits have been reported from sulbutiamine:

Reduced mental fatigue

Increases mental focus

Increases alertness

Improves memory

Reduces stress and anxiety

Improved erectile function

1-3 capsules per day.

COMPOSITION

Serving Size: 1
Servings Per Container: 100

Amount Per Serving:

Sulbutiamine -  200mg