Epistane has earned itself the
crown of reigning pound for pound king of prohormones. As well as being
the bestselling prohormone in town, Epistane is the perfect choice for
athletes (as it does not cause water retention), as well as for those
interested in lean, high quality muscle gains with an absence of
bloating.
IBE Epistane - Finally the PRO-Anabolic, anti-estrogen we
have all been waiting for has arrived!
Epistane, exhibits a strong, long lasting anti-estrogen
effect that is organ tissue specific. This means it works only where
you want it to work. Broad range estrogen blockers and aromatase
inhibitors can result in system shut down, aching joints, and decreased
IGF-I expression. Epistane binds
specifically to the 17 beta-estradiol receptor protein in the
target tissues. Because of its long lasting and strong effects on
specific tissue, Epistane can
significantly reduce and reverse the effects of gynocomastia because
not only does Epistane
specifically block estrogen in breast tissue but it induces an
estrogen-depleted condition which leads to apoptosis or the death of
the breast tissue cells. Studies show that small doses of the parent
compound, Epitiostanol, at just 10-20mg/week showed a complete
disappearance of the mass and pain in 25% of the male patients in the
clinical trail, while the other 75% of the patients showed at least a
50% reduction in the mass and complete loss of pain in just 4-8 weeks.
That’s results in 100% of the male users with no side
effects. While compounds such as Clomid and Nolvadex also block the 17
beta-estradiol receptor,
they do not elicit the same increase in protein synthesis and strength
gains that Epistane
can offer.
Epistane is more than
an anti-estrogen, though, as it also binds to androgen receptors in
skeletal muscle. As a PRO-Anabolic compound Epistane promotes
increases in strength and lean body mass with an anabolic/androgenic
value (Q ratio) of 12. With most powerful androgens there is a high
risk of the natural suppression of the gonads. Epistane, unlike other
PRO-Anabolic compounds that have recently been released, is relatively
mild on the gonads and, due to the anti-estrogenic effects and the fact
that Epistane
keeps LH levels elevated, post cycle therapy becomes a breeze. All
effects combined make Epistane a great
compound to produce dry, lean gains in muscle mass with minimal side
effects and suppression of the body’s natural androgen
production, while lowering the effects of natural estrogen or combating
estrogen from endogenous/exogenous sources. This makes it a powerful
tool when combined with “wet” compounds in attempt
to increase gains and decrease side effects. One can also not overlook
the potential benefit of this compound taken alone, especially when
recovering from periods of “wet” compounds. If you
don’t want to worry about how your lipid and liver values are
doing and whether or not you are going to get gynocomastia or not then
get Epistane,
stop worrying, and experience what others are raving about!
FAQ
- What can one expect from Epistane?
- Incredible
Strength Gains
- Dry, Lean Mass
Gains
- Gynocomastia
Protection
- Increased
Libido
- Increased
Training Intensity and Sense of Well-Being
- In Some,
Reductions in Gynocomastia!
What is a
typical cycle of Epistane?
A typical cycle of Epistane lasts
3-5 weeks and has a range of dosages around 20-40mg. Most people run a
cycle similar to 20/30/30/40 or some variation. Others, looking for
large mass gains, are running 40mg for 4 weeks or more. It is important
to ramp up the dosage in the beginning, even if only for a few days.
What is
pulse cycling? (posted in the Epistane forum at IBE,
written by Dr.D)
Dosing something to intentionally
avoid long term sides, such as HTPA suppression and liver damage. With
pulsing, the serious, long term side effects of chronic oral treatment
are avoided and short term side effect, like acne and mineral
retention, are milder that usual. This allows for higher dosages to be
used. Basically, if you dosed on an ED basis you would get 100% effect,
100% short term sides and 100% long term sides. If you dose EOD on a
pulse protocol, you still get about 60% effect, 75% short term sides
but only about 40% of the long term sides. That's not a bad trade off
and very economical on the body and the wallet too! Of course if you
would have gained 10lbs this means you will only gain 6lbs pulsing, but
it also means you can do this for 2 or 3 times longer than a normal
cycle. That equals about 2 months of worry free dosing, so the net
effect is a gain of about 12lbs instead of 10lbs over twice the time
frame with less sides and a milder PCT requirement if even needed at
all. It's a great long term strategy and good for newer users looking
to run fast, clean, cycles for 1 month with no PCT needed later. That's
how I perfected it. There are two basic approaches to do it: EOD or
2on/2off depending on your workout schedule. Doses can be high
(30-40mg) but take them close together preferably before 6pm (1 dose
pre and 1 dose post-w/o instead of spread out like normal) or doses can
be lower (10-20mg) if you want to stretch it to 2 or 3 months instead
of just 1. Dose at least 3 times per week but not more than 4.
How Epistane
Works
Battling Gyno
Estradiol is
the strongest form of estrogen in the human body, effecting several
organs. Estradiol enters cells freely and interacts with a cytoplasmic
target cell receptor (ER alpha and ER beta). When the
estrogen receptor has bound
its
ligand it can enter the nucleus of the target cell and regulate gene
transcription which leads to formation of messenger RNA. The mRNA
interacts with ribosomes to produce specific proteins that express the
effect of estradiol upon the target cell. Epistane works by binding and
deactivating the ER beta
so that no
estrodiol-elicited effects can be carried out in the cell. In the case
of breast tissue ER beta
is the
primary target receptor responsible for growth and proliferation. Epistane binds to the
ER beta and
not only
disables the receptor from binding to estradiol, it actually puts the
cell in an estrogen deprived state, which decreases the cells viability
and leads to a decrease in size and eventual cell death. Other SERMs
also block the ER beta
receptor and
AI’s even block the formation of Estradiol from testosterone
conversion. However, the effectiveness at the receptor and long term
side effects vary. Epistane
has been shown to have one of the strongest and longest effects at the
binding site, with minimal side effects when compared to other
anti-estrogens.
Epistane
- Increasing Lean Body Mass
Epistane also binds
to androgen receptors located on skeletal muscle cells and muscle stem
cells. This then leads to changes in muscle cell function and protein
synthesis. In the case of muscle stem cells, they will actually change
and fuse with your active adult skeletal muscles increasing the muscles
potential for growth and repair. On the opposing side, the presence of
androgens actually decreases the ability of stem cells to form new fat
cells. So you now have increased stem cell conversion to muscle cells
and decreased stem cell conversion to fat cells, giving you more
positive effects out of your nutrition and training.
Stacking Options:
We suggest
combining Epistane with a product from our liver support category for
overall health. For enhanced gains, run this with Activate Xtreme which
by binding to SHGB will enhance the effectiveness of the Epistane. Post
cycle we recommend combining Epistane with Lean Xtreme and Activate
Xtreme to help sustain the muscle gains.
Epistane Supplement Facts
Serving Size: 2 capsules
Servings per Container: 45
|
|
| |
| |
Amount Per Serving |
% Daily Value |
| 2,3a-Epithio-17a-methyletioallo
cholan-17b-ol |
20 mg |
** |
|
|
|
Directions:
As a dietary
supplement, take 1-3
capsules of Epistane daily as needed or as directed by your physician.
WARNING:
KEEP OUT OF REACH
OF
CHILDREN. Consult your physician before using this dietary
supplement. Do not use this product if you are at risk or are
being treated for high blood pressure, heart, kidney, thyroid, or
psychiatric disease, difficulty in urinating, prostate enlargement,
anxiety, depression, seizure disorder, or stroke. Consult
your healthcare professional before use if you are taking any
prescription drugs. Consult your healthcare practioner before
beginning any weight loss program.
